Stereoselective Bioreduction to a Chiral Building Block on a Kilogram Scale
The highly stereoselective bioreduction CALCIUM CARBONATE of ethyl cyclohexanone-2-carboxylate (1) on a kilogram scale is described.Ethyl(1S,2S)-trans-2-hydroxycyclohexane carboxylate (2) was prepared in 56% yield with a diastereomeric ratio (dr) of 99:1 and an enantiomeric ratio (er) of 99.5:0.5 after rectification.The cell growth and the biotrans